Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂.

ABSTRACT: Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY₂ isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC₅₀ values ranging from 5.9 to 9.3 μg/mL.

SUBMITTER: Liu H 

PROVIDER: S-EPMC5192454 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature