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Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY?.

ABSTRACT: Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl peniphenone (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY? isolated from the leaves of Sonneratia apetala. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds 1, 3, 5, and 7 showed potent immunosuppressive activity with IC50 values ranging from 5.9 to 9.3 ?g/mL.

SUBMITTER: Liu H 

PROVIDER: S-EPMC5192454 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Polyketides with Immunosuppressive Activities from Mangrove Endophytic Fungus Penicillium sp. ZJ-SY₂.

Liu Hongju H   Chen Senhua S   Liu Weiyang W   Liu Yayue Y   Huang Xishan X   She Zhigang Z  

Marine drugs 20161125 12

Nine polyketides, including two new benzophenone derivatives, peniphenone (<b>1</b>) and methyl peniphenone (<b>2</b>), along with seven known xanthones (<b>3</b>-<b>9</b>) were obtained from mangrove endophytic fungus <i>Penicillium</i> sp. ZJ-SY₂ isolated from the leaves of <i>Sonneratia apetala</i>. Their structures were elucidated on the basis of MS, 1D, and 2D NMR data. Compounds <b>1</b>, <b>3</b>, <b>5</b>, and <b>7</b> showed potent immunosuppressive activity with IC<sub>50</sub> values  ...[more]

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