A GWAS follow-up of obesity-related SNPs in SYPL2 reveals sex-specific association with hip circumference.

ABSTRACT:

Objective

A novel single-nucleotide polymorphism (SNP) associated with morbid obesity was recently identified by exome sequencing. The purpose of this study was to follow up this low-frequency coding SNP located within the SYPL2 locus and associated with body mass index in order to reveal novel associations with obesity-related traits.

Methods

The body mass index-associated SNP (rs62623713 A>G [chr1:109476817/hg19]) and two tagging SNPs within the SYPL2 locus, rs9661614 T>C (chr1:109479215) and rs485660 G>A (chr1:109480810), were genotyped in the obesity (n = 3,017) and the infogene (n = 676) cohorts, which were further combined, leading to a larger cohort of 3,693 individuals. Association testing was performed by general linear models in the obes

SUBMITTER: de Toro-Martin J 

PROVIDER: S-EPMC5192540 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature