Local Turgor Pressure Reduction via Channel Clustering.

ABSTRACT: The primary drivers of yeast endocytosis are actin polymerization and curvature-generating proteins, such as clathrin and BAR domain proteins. Previous work has indicated that these factors may not be capable of generating the forces necessary to overcome turgor pressure. Thus local reduction of the turgor pressure, via localized accumulation or activation of solute channels, might facilitate endocytosis. The possible reduction in turgor pressure was calculated numerically, by solving the diffusion equation through a Legendre polynomial expansion. It was found that for a region of increased permeability having radius 45 nm, as few as 60 channels with a spacing of 10 nm could locally decrease the turgor pressure by 50%. We identified a key dimensionless parameter, p = P₁a/D, wher

SUBMITTER: Scher-Zagier JK 

PROVIDER: S-EPMC5192740 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature