Do K_V 7.1 channels contribute to control of arterial vascular tone?

ABSTRACT:

Background and purpose

K_V 7.1 voltage-gated potassium channels are expressed in vascular smooth muscle cells (VSMC) of diverse arteries, including mesenteric arteries. Based on pharmacological evidence using R-L3 (K_V 7.1 channel opener), HMR1556, chromanol 293B (K_V 7.1 channel blockers), stimulation of these channels has been suggested to evoke profound relaxation in various vascular beds of rats. However, the specificity of these drugs in vivo is uncertain.

Experimental approach

We used Kcnq1^-/- mice and pharmacological tools to determine whether K_V 7.1 channels play a role in the regulation of arterial tone.

Key results

R-L3 produced similar concentration-dependent relaxations (EC₅₀  ~ 1.4 μM) of arte

SUBMITTER: Tsvetkov D 

PROVIDER: S-EPMC5192887 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature