Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome.

ABSTRACT:

Background

Pineal parenchymal tumors (PPTs) are rare neoplasms of the central nervous system, and data concerning clinical outcomes are limited. The purpose of this study was to define the clinical behavior of PPT according to current histopathologic criteria and identify prognostic factors to guide therapeutic decisions.

Methods

Seventy-five patients treated for PPT at a single institution between 1992 and 2015 were retrospectively identified. Forty-five resection specimens were available and re-reviewed. Freedom from progression (FFP) and overall survival (OS) were estimated using the Kaplan-Meier method and compared using log-rank tests.

Results

Median follow-up was 4.1 years. All patients initially underwent surgery; 78% of patients with PPT of intermediate differ

SUBMITTER: Raleigh DR 

PROVIDER: S-EPMC5193017 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature