Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells.

ABSTRACT:

Background

Glioma is the most common form of primary malignant brain tumor in adults, with approximately 4 cases per 100 000 people each year. Gliomas, like many tumors, are thought to primarily metabolize glucose for energy production; however, the reliance upon glycolysis has recently been called into question. In this study, we aimed to identify the metabolic fuel requirements of human glioma cells.

Methods

We used database searches and tissue culture resources to evaluate genotype and protein expression, tracked oxygen consumption rates to study metabolic responses to various substrates, performed histochemical techniques and fluorescence-activated cell sorting-based mitotic profiling to study cellular proliferation rates, and employed an animal model of malignant glioma

SUBMITTER: Lin H 

PROVIDER: S-EPMC5193020 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature