CXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone.

ABSTRACT:

Background

Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that might arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated that GSCs are able to escape the tumor mass and preferentially colonize the adult subventricular zone (SVZ). At a distance from the initial tumor site, these GSCs might therefore represent a high-quality model of clinical resilience to therapy and cancer relapses as they specifically retain tumor-initiating abilities.

Method

While relying on recent findings that have validated the existence of GSCs in the human SVZ, we questioned the role of the SV

SUBMITTER: Goffart N 

PROVIDER: S-EPMC5193023 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature