Systemic therapy of brain metastases: non-small cell lung cancer, breast cancer, and melanoma.

ABSTRACT: Brain metastases (BM) occur frequently in many cancers, particularly non-small cell lung cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with poor prognosis and has an adverse impact on survival and quality of life. Commonly used therapies for BM such as surgery or radiotherapy are associated with only modest benefits. However, recent advances in systemic therapy of many cancers have generated considerable interest in exploration of those therapies for treatment of intracranial metastases.This review discusses the epidemiology of BM from the aforementioned primary tumors and the challenges of using systemic therapies for metastatic disease located within the central nervous system. Cumulative data from several retrospective and small prospective studies sug

SUBMITTER: Chamberlain MC 

PROVIDER: S-EPMC5193029 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature