Cryptococcus neoformans UGT1 encodes a UDP-Galactose/UDP-GalNAc transporter.

ABSTRACT: Cryptococcus neoformans, an opportunistic fungal pathogen, produces a glycan capsule to evade the immune system during infection. This definitive virulence factor is composed mainly of complex polysaccharides, which are made in the secretory pathway by reactions that utilize activated nucleotide sugar precursors. Although the pathways that synthesize these precursors are known, the identity and the regulation of the nucleotide sugar transporters (NSTs) responsible for importing them into luminal organelles remain elusive. The UDP-galactose transporter, Ugt1, was initially identified by homology to known UGTs and glycan composition analysis of ugt1Δ mutants. However, sequence is an unreliable predictor of NST substrate specificity, cells may express multiple NSTs with overlapping specificit

SUBMITTER: Li LX 

PROVIDER: S-EPMC5193108 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature