Early Improvement in Psychosocial Function Predicts Longer-Term Symptomatic Remission in Depressed Patients.

ABSTRACT: The goal of this study was to evaluate the relationship between early change in psychosocial function independent of depression severity and longer-term symptomatic remission. Participants of Combining Medications to Enhance Depression Outcomes trial were randomly selected for model selection (n = 334) and validation (n = 331). Changes in psychosocial function (Work and Social Adjustment Scale, WSAS) from baseline to week 6 were assessed and two data-driven sub-groups of WSAS change were identified in the randomly selected model selection half. Results of analyses to predict symptomatic remission at 3 and 7 months were validated for these sub-groups in the second half (validation sample). From baseline to week 6, psychosocial function improved significantly even after adjusting for depress

SUBMITTER: Jha MK 

PROVIDER: S-EPMC5193346 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature