Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury.

ABSTRACT:

Background

Epicardial adipose tissue volume and coronary artery disease are strongly associated, even after accounting for overall body mass. Despite its pathophysiological significance, the origin and paracrine signaling pathways that regulate epicardial adipose tissue's formation and expansion are unclear.

Methods

We used a novel modified mRNA-based screening approach to probe the effect of individual paracrine factors on epicardial progenitors in the adult heart.

Results

Using 2 independent lineage-tracing strategies in murine models, we show that cells originating from the Wt1⁺ mesothelial lineage, which includes epicardial cells, differentiate into epicardial adipose tissue after myocardial infarction. This differentiation process required Wt1 expressi

SUBMITTER: Zangi L 

PROVIDER: S-EPMC5195872 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature