GABA-producing Bifidobacterium dentium modulates visceral sensitivity in the intestine.

ABSTRACT:

Background

Recurrent abdominal pain is a common and costly health-care problem attributed, in part, to visceral hypersensitivity. Increasing evidence suggests that gut bacteria contribute to abdominal pain perception by modulating the microbiome-gut-brain axis. However, specific microbial signals remain poorly defined. γ-aminobutyric acid (GABA) is a principal inhibitory neurotransmitter and a key regulator of abdominal and central pain perception from peripheral afferent neurons. Although gut bacteria are reported to produce GABA, it is not known whether the microbial-derived neurotransmitter modulates abdominal pain.

Methods

To investigate the potential analgesic effects of microbial GABA, we performed daily oral administration of a specific Bifidobacterium strain (B. dent

SUBMITTER: Pokusaeva K 

PROVIDER: S-EPMC5195897 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature