Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease.

ABSTRACT:

Importance

The accumulation of aggregated β-amyloid and tau proteins into plaques and tangles is a central feature of Alzheimer disease (AD). While plaque and tangle accumulation likely contributes to neuron and synapse loss, disease-related changes to oligodendrocytes and myelin are also suspected of playing a role in development of AD dementia. Still, to our knowledge, little is known about AD-related myelin changes, and even when present, they are often regarded as secondary to concomitant arteriosclerosis or related to aging.

Objective

To assess associations between hallmark AD pathology and novel quantitative neuroimaging markers while being sensitive to white matter myelin content.

Design, setting, and participants

Magnetic resonance imaging was performed at an

SUBMITTER: Dean DC 

PROVIDER: S-EPMC5195903 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature