Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Purpose

Local tumor growth is a major cause of morbidity and mortality in nearly 30% of patients with pancreatic ductal adenocarcinoma (PDAC). Radiotherapy is commonly used for local disease control in PDAC, but its efficacy is limited. We studied the impact of selectively intervening on radiotherapy-induced inflammation as an approach to overcome resistance to radiotherapy in PDAC.

Experimental design

PDAC cell lines derived from primary pancreatic tumors arising spontaneously in Kras^LSL-G12D/+;Trp53^LSL-R172H/+;Pdx-1 Cre mice were implanted into syngeneic mice and tumors were focally irradiated using the Small Animal Radiation Research Platform (SARRP). We determined the impact of depleting T cells and Ly6C⁺ monocytes as well as inhibiting t

SUBMITTER: Kalbasi A 

PROVIDER: S-EPMC5195913 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature