Preclinical Applications of 3'-Deoxy-3'-[¹⁸F]Fluorothymidine in Oncology - A Systematic Review.

ABSTRACT: The positron emission tomography (PET) tracer 3'-deoxy-3'-[¹⁸F]fluorothymidine ([¹⁸F]FLT) has been proposed to measure cell proliferation non-invasively in vivo. Hence, it should provide valuable information for response assessment to tumor therapies. To date, [¹⁸F]FLT uptake has found limited use as a response biomarker in clinical trials in part because a better understanding is needed of the determinants of [¹⁸F]FLT uptake and therapy-induced changes of its retention in the tumor. In this systematic review of preclinical [¹⁸F]FLT studies, comprising 174 reports, we identify the factors governing [¹⁸F]FLT uptake in tumors, among which thymidine kinase 1 plays a primary role. The majority of publications (83 %) repor

SUBMITTER: Schelhaas S 

PROVIDER: S-EPMC5196884 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature