Unusual Legionnaires' outbreak in cool, dry Western Canada: an investigation using genomic epidemiology.

ABSTRACT: An outbreak of Legionnaires' disease occurred in an inner city district in Calgary, Canada. This outbreak spanned a 3-week period in November-December 2012, and a total of eight cases were identified. Four of these cases were critically ill requiring intensive care admission but there was no associated mortality. All cases tested positive for Legionella pneumophila serogroup 1 (LP1) by urinary antigen testing. Five of the eight patients were culture positive for LP1 from respiratory specimens. These isolates were further identified as Knoxville monoclonal subtype and sequence subtype ST222. Whole-genome sequencing revealed that the isolates differed by no more than a single vertically acquired single nucleotide variant, supporting a single point-source outbreak. Hypothesis-based environmen

SUBMITTER: Knox NC 

PROVIDER: S-EPMC5197926 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature