Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity.

ABSTRACT:

Objective

Although polymorphisms in suppressor of cytokine signaling 3 (SOCS3) was reported to be related to obesity, Metabolic syndrome (MS), and type 2 diabetes mellitus in various adult studies, there is a lack of data in children. In this study, we examined eight reported polymorphisms of SOCS3 in obese Turkish children and adolescent with and without MS and compared the results with that of controls.

Methods

One hundred and forty eight obese and 63 age- and sex-matched control subjects were enrolled in the study. Obesity classification was carried out according to body mass index. World Health Organization and National Cholesterol Education Program criteria were used for the diagnosis of MS. Genotyping procedure was carried out by polymerase chain reaction and Sanger se

SUBMITTER: Boyraz M 

PROVIDER: S-EPMC5198005 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature