Canagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects.

ABSTRACT: Sodium-glucose cotransporter 2 inhibition with canagliflozin decreases HbA1c, body weight, BP, and albuminuria, implying that canagliflozin confers renoprotection. We determined whether canagliflozin decreases albuminuria and reduces renal function decline independently of its glycemic effects in a secondary analysis of a clinical trial in 1450 patients with type 2 diabetes receiving metformin and randomly assigned to either once-daily canagliflozin 100 mg, canagliflozin 300 mg, or glimepiride uptitrated to 6-8 mg. End points were annual change in eGFR and albuminuria over 2 years of follow-up. Glimepiride, canagliflozin 100 mg, and canagliflozin 300 mg groups had eGFR declines of 3.3 ml/min per 1.73 m² per year (95% confidence interval [95% CI], 2.8 to 3.8), 0.5 ml/min per 1.73

SUBMITTER: Heerspink HJ 

PROVIDER: S-EPMC5198289 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature