Gene expression alterations in the medial prefrontal cortex and blood cells in a mouse model of depression during menopause.

ABSTRACT:

Aims

The prevalence of major depressive disorder (MDD) is higher in women than in men, and this may be due to the decline in estrogen levels that occurs during the menopausal transition. We studied the biological alterations in the medial prefrontal cortex (mPFC), which is a region that is highly implicated in the neurobiology of MDD, and the blood cells (BCs) of ovariectomized (OVX) mice subjected to chronic mild stress (CMS), which represents a mouse model of depression during menopause.

Main methods

The mPFC and the BCs were obtained from the same individuals. Gene expression levels were analyzed by microarray. The data were used for the Ingenuity Pathway Analysis and the Gene Ontology analysis.

Key findings

The gene expression alterations (GEAs) induced by OVX wer

SUBMITTER: Miyata S 

PROVIDER: S-EPMC5198744 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature