A dual role for Caspase8 and NF-<i>κ</i>B interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival.

ABSTRACT: Ovarian cancer is a deadly disease characterized by primary and acquired resistance to chemotherapy. We previously associated NF-κB signaling with poor survival in ovarian cancer, and functionally demonstrated this pathway as mediating proliferation, invasion and metastasis. We aimed to identify cooperating pathways in NF-κB-dependent ovarian cancer cells, using genome-wide RNA interference as a loss-of-function screen for key regulators of cell survival with IKKβ inhibition. Functional genomic screen for interactions with NF-κB in ovarian cancer showed that cells depleted of Caspase8 died better with IKKβ inhibition. Overall, low Caspase8 was associated with shorter overall survival in three independent gene expression data sets of ovarian cancers. Conve

SUBMITTER: Hernandez L 

PROVIDER: S-EPMC5198842 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature