Par-1b is required for morphogenesis and differentiation of myoepithelial cells during salivary gland development.

ABSTRACT: The salivary epithelium initiates as a solid mass of epithelial cells that are organized into a primary bud that undergoes morphogenesis and differentiation to yield bilayered acini consisting of interior secretory acinar cells that are surrounded by contractile myoepithelial cells in mature salivary glands. How the primary bud transitions into acini has not been previously documented. We document here that the outer epithelial cells subsequently undergo a vertical compression as they express smooth muscle α-actin and differentiate into myoepithelial cells. The outermost layer of polarized epithelial cells assemble and organize the basal deposition of basement membrane, which requires basal positioning of the polarity protein, Par-1b. Whether Par-1b is required for the vertical compression

SUBMITTER: Gervais EM 

PROVIDER: S-EPMC5198941 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature