CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance.

ABSTRACT: CITED2 (Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2) is a member of the CITED family and is involved in various cellular functions during development and differentiation. Mounting evidence suggests the importance of CITED in the progression of human malignancies, but the significance of CITED2 protein has not yet been examined in breast carcinoma. Therefore, in the present study, we examined the clinical significance and the biological functions of CITED2 in breast carcinoma by immunohistochemistry and in vitro study. CITED2 immunoreactivity was detected in breast carcinoma tissues, and it was significantly higher compared to those in morphologically normal mammary glands. CITED2 immunoreactivity was significantly associated with stage, pathological T

SUBMITTER: Minemura H 

PROVIDER: S-EPMC5198946 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature