Rofecoxib-Induced Deleterious Effects Escape Detection by Organismal Performance Assays.

ABSTRACT:

Background

Organismal Performance Assays (OPAs) are a unique toxicity quantification method used to assess the safety of potentially toxic compounds, such as pharmaceuticals. OPAs utilize genetically diverse wild mice (Mus musculus) housed in semi-natural enclosures wherein exposed individuals compete directly with controls for resources. Previously, OPAs have been successful in detecting adverse effects in mice that were exposed to paroxetine. Here, we further test OPAs utility in pharmaceutical safety assessment by testing OPAs with rofecoxib, a drug with known adverse effects in humans.

Methods

We exposed mice to rofecoxib (~37.5 mg/kg/day) during gestation and into early adulthood. Exposure ceased when individuals were released into enclosures. Five independent po

SUBMITTER: Gaukler SM 

PROVIDER: S-EPMC5199028 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature