CO2 Cluster Ion Beam, an Alternative Projectile for Secondary Ion Mass Spectrometry.

ABSTRACT: The emergence of argon-based gas cluster ion beams for SIMS experiments opens new possibilities for molecular depth profiling and 3D chemical imaging. These beams generally leave less surface chemical damage and yield mass spectra with reduced fragmentation compared with smaller cluster projectiles. For nanoscale bioimaging applications, however, limited sensitivity due to low ionization probability and technical challenges of beam focusing remain problematic. The use of gas cluster ion beams based upon systems other than argon offer an opportunity to resolve these difficulties. Here we report on the prospects of employing CO2 as a simple alternative to argon. Ionization efficiency, chemical damage, sputter rate, and beam focus are investigated on model compounds using a series of CO2 and

SUBMITTER: Tian H 

PROVIDER: S-EPMC5199235 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature