Ontology highlight
ABSTRACT:
SUBMITTER: Miyake K
PROVIDER: S-EPMC5199237 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cell reports 20161101 8
Calcium-dependent activator protein for secretion 1 (CAPS1) plays a distinct role in the priming step of dense core vesicle (DCV) exocytosis. CAPS1 pre-mRNA is known to undergo adenosine-to-inosine RNA editing in its coding region, which results in a glutamate-to-glycine conversion at a site in its C-terminal region. However, the physiological significance of CAPS1 RNA editing remains elusive. Here, we created mutant mice in which edited CAPS1 was solely expressed. These mice were lean due to in ...[more]