Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature.

Methods

From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis.

Results

We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be re

SUBMITTER: Velseboer DC 

PROVIDER: S-EPMC5199613 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature