Principles of Kinase Inhibitor Therapy for Solid Tumors.

ABSTRACT:

Objective

We aimed to identify key principles of targeted therapy of protein kinases and their application to the management of solid tumors.

Background

Concurrent advances in tumor genomic analysis and molecular inhibitor development have dramatically impacted the diagnosis and treatment of solid tumors, and common themes regarding the use of kinase inhibitors are developing.

Methods

The list of kinase inhibitors that have been approved by the US Food and Drug Administration was reviewed and articles related to the agents were searched in the PubMed database up until December 2015. We included pivotal, randomized controlled phase 2 and 3 trials, and also pertinent preclinical studies.

Results

Small molecule inhibitors targeted against driver kinases, overactiv

SUBMITTER: Cohen NA 

PROVIDER: S-EPMC5199628 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature