Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids.

ABSTRACT:

Background and objective

Porphyromonas gingivalis is considered a major pathogen of chronic periodontitis, which also may be implicated with systemic diseases such as atherosclerosis. Secreted cysteine proteases, gingipains Rgp and Kgp, are essential for P. gingivalis virulence. Some polyphenols and flavonoids are known to inhibit gingipain activity and interfere with biofilm formation by P. gingivalis. Many bioactive compounds have been isolated from Epimedium species, but availability of these compounds on gingipains and P. gingivalis is still unclear. Therefore, the aim of this study was to evaluate natural products from medical plants to develop a new therapeutic agent against periodontal disease.

Material and methods

Prenylated flavonoids were isolated from Epimedium sp

SUBMITTER: Kariu T 

PROVIDER: S-EPMC5199630 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature