An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells.

ABSTRACT: p40, a Lactobacillus rhamnosus GG (LGG)-derived protein, transactivates epidermal growth factor receptor (EGFR) in intestinal epithelial cells, leading to amelioration of intestinal injury and inflammation. To elucidate mechanisms by which p40 regulates mucosal immunity to prevent inflammation, this study aimed to determine the effects and mechanisms of p40 on regulation of a proliferation-inducing ligand (APRIL) expression in intestinal epithelial cells for promoting immunoglobulin A (IgA) production. p40 upregulated April gene expression and protein production in mouse small intestine epithelial (MSIE) cells, which were inhibited by blocking EGFR expression and kinase activity. Enteroids from Egfr^fl/fl, but not Egfr^fl/fl-Vil-Cre mice with EGFR specifically deleted i

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5199635 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature