The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.

ABSTRACT: Cardiac hypertrophic growth in response to pathological cues is associated with reexpression of fetal genes and decreased cardiac function and is often a precursor to heart failure. In contrast, physiologically induced hypertrophy is adaptive, resulting in improved cardiac function. The processes that selectively induce these hypertrophic states are poorly understood. Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K27me3, which are involved in stable cellular differentiation, specifically in cardiomyocytes from physiologically and pathologically hypertrophied rat hearts, and correlated these marks with their associated transcriptomes. This analysis revealed the pervasive loss of euchromatic H3K9me2 as a conserved feature of pathological hypertrophy that was associated

SUBMITTER: Thienpont B 

PROVIDER: S-EPMC5199699 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature