Prolonged red cell storage before transfusion increases extravascular hemolysis.

ABSTRACT:

Background

Some countries have limited the maximum allowable storage duration for red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 weeks, but randomized trials have not assessed the effects of this final week of storage on clinical outcomes.

Methods

Sixty healthy adult volunteers were randomized to a single standard, autologous, leukoreduced, packed red cell transfusion after 1, 2, 3, 4, 5, or 6 weeks of storage (n = 10 per group). 51-Chromium posttransfusion red cell recovery studies were performed and laboratory parameters measured before and at defined times after transfusion.

Results

Extravascular hemolysis after transfusion progressively increased with increasing storage time (P < 0.001 for linear trend in the AUC of s

SUBMITTER: Rapido F 

PROVIDER: S-EPMC5199711 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature