Sleep-related hypermotor epilepsy: Long-term outcome in a large cohort.

ABSTRACT:

Objective

To assess the long-term outcome of sleep-related hypermotor epilepsy (SHE).

Methods

We retrospectively reconstructed a representative cohort of patients diagnosed with SHE according to international diagnostic criteria, sleep-related seizures ≥75% and follow-up ≥5 years. Terminal remission (TR) was defined as a period of ≥5 consecutive years of seizure freedom at the last follow-up. We used Kaplan-Meier estimates to calculate the cumulative time-dependent probability of TR and to generate survival curves. Univariate and multivariate Cox regression analyses were performed.

Results

We included 139 patients with a 16-year median follow-up (2,414 person-years). The mean age at onset was 13 ± 10 years. SHE was sporadic in 86% of cases and familial in 14%; 16% of

SUBMITTER: Licchetta L 

PROVIDER: S-EPMC5200852 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature