Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study.

ABSTRACT:

Objective

As previous research has suggested that exposure to vitamin D insufficiency in utero may have relevance for the risk of multiple sclerosis (MS), we aimed to examine the direct association between level of neonatal vitamin D and risk of MS.

Methods

We carried out a matched case-control study. Dried blood spots samples (DBSS) belonging to 521 patients with MS were identified in the Danish Newborn Screening Biobank. For every patient with MS, 1-2 controls with the same sex and birth date were retrieved from the Biobank (n = 972). Level of 25-hydroxyvitamin D (25[OH]D) in the DBSS was measured using liquid chromatography tandem mass spectroscopy. The association between different levels of 25(OH)D and risk of MS was evaluated by odds ratios (OR) calculated in condition

SUBMITTER: Nielsen NM 

PROVIDER: S-EPMC5200855 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature