Effects of orthostatic hypotension on cognition in Parkinson disease.

ABSTRACT:

Objective

To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and within-group design.

Methods

Individuals without dementia with idiopathic PD included 18 with OH (PDOH) and 19 without OH; 18 control participants were also included. Neuropsychological tests were conducted in supine and upright-tilted positions. Blood pressure was assessed in each posture.

Results

The PD groups performed similarly while supine, demonstrating executive dysfunction in sustained attention and response inhibition, and reduced semantic fluency and verbal memory (encoding and retention). Upright posture exacerbated and broadened these deficits in the PDOH group to include phonemic fluency

SUBMITTER: Centi J 

PROVIDER: S-EPMC5200856 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature