T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients.

ABSTRACT: Type 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell receptors (TCRs), we used a high-throughput immune repertoire sequencing technique to profile the spectrum of TCRs in individual T1D patients and controls. We sequenced the T cell repertoire of nine T1D patients, four type 2 diabetes (T2D) patients, and six nondiabetic controls. The diversity of the T cell repertoire in T1D patients was significantly decreased in comparison with T2D patients (P=7.0E-08 for CD4⁺ T cells, P=1.4E-04 for CD8⁺ T cells) and nondiabetic controls (P=2.7E-09 for CD4⁺ T cells, P=7.6E-06 for CD8⁺ T cells)

SUBMITTER: Tong Y 

PROVIDER: S-EPMC5200939 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature