Four-dimensional planning for motion synchronized dose delivery in lung stereotactic body radiation therapy.

ABSTRACT:

Background and purpose

To investigate a weighted four-dimensional (W-4D) treatment planning strategy based on the greater clinical advantage of the conformal over the intensity-modulated technique in lung stereotactic body radiotherapy (SBRT).

Material and methods

Two planning strategies (individual-phase 4D [IP-4D] and W-4D) were evaluated in eighteen lung SBRT patients. The IP-4D plan can deliver a constant fluence during whole respiratory phases. The W-4D plan's key concept was to escalate (or reduce) fluence using a 4D optimization algorithm when the tumour target was out-of-line (or in-line) with an organ-at-risk. The fluence was converted to a dynamic multi-leaf collimator leaf sequence for deliverable 4D irradiation.

Results

In all patients, the W-4D plan enabl

SUBMITTER: Tachibana H 

PROVIDER: S-EPMC5201122 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature