The impact of prolapse mesh on vaginal smooth muscle structure and function.

ABSTRACT:

Objective

To evaluate the impact of prolapse meshes on vaginal smooth muscle structure (VaSM) and function, and to evaluate these outcomes in the context of the mechanical and textile properties of the mesh.

Design

Three months following the implantation of three polypropylene prolapse meshes with distinct textile and mechanical properties, mesh tissue explants were evaluated for smooth muscle contraction, innervation, receptor function, and innervation density.

Setting

Magee-Womens Research Institute at the University of Pittsburgh.

Population

Thirty-four parous rhesus macaques of similar age, parity, and pelvic organ prolapse quantification (POP-Q) scores.

Methods

Macaques were implanted with mesh via sacrocolpopexy. The impact of Gynemesh(™)  PS (Ethi

SUBMITTER: Jallah Z 

PROVIDER: S-EPMC5201168 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature