Subfertility and Risk of Testicular Cancer in the EPSAM Case-Control Study.

ABSTRACT:

Background/objectives

It has been suggested that subfertility and testicular cancer share genetic and environmental risk factors. We studied both subfertility and the strongest known testicular cancer susceptibility gene, the c-KIT ligand (KITLG), whose pathway is involved in spermatogenesis.

Methods

The EPSAM case-control study is comprised of testicular cancer patients from the Province of Turin, Italy, diagnosed between 1997 and 2008. The present analysis included 245 cases and 436 controls from EPSAM, who were aged 20 years or older at diagnosis/recruitment. The EPSAM questionnaire collected information on factors such as number of children, age at first attempt to conceive, duration of attempt to conceive, use of assisted reproduction techniques, physician-assigned diag

SUBMITTER: Grasso C 

PROVIDER: S-EPMC5201268 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature