A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans.

ABSTRACT: Safeguarding the proteome is central to the health of the cell. In multi-cellular organisms, the composition of the proteome, and by extension, protein-folding requirements, varies between cells. In agreement, chaperone network composition differs between tissues. Here, we ask how chaperone expression is regulated in a cell type-specific manner and whether cellular differentiation affects chaperone expression. Our bioinformatics analyses show that the myogenic transcription factor HLH-1 (MyoD) can bind to the promoters of chaperone genes expressed or required for the folding of muscle proteins. To test this experimentally, we employed HLH-1 myogenic potential to genetically modulate cellular differentiation of Caenorhabditis elegans embryonic cells by ectopically expressing HLH-1 in all ce

SUBMITTER: Bar-Lavan Y 

PROVIDER: S-EPMC5201269 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature