Proteomic Analysis of Kidney Preservation Solutions Prior to Renal Transplantation.

ABSTRACT: One of the main issues in kidney transplantation is the optimal functional preservation of the organ until its transplantation into the appropriate recipient. Despite intensive efforts, the functional preservation period remains limited to hours. During this time, as a result of cellular injury, various proteins, peptides, and other molecules are released by the organ into the preservation medium. In this study, we used proteomic techniques to analyze the protein profiles of preservation solutions in which organs had been preserved prior to their transplantation. Samples were obtained from the preservation solutions of 25 deceased donor kidneys scheduled for transplantation. The protein profiles of the solutions were analyzed using 2D gel electrophoresis/MALDI-TOF and LC-MS/MS. We identifi

SUBMITTER: Coskun A 

PROVIDER: S-EPMC5201308 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature