Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies.

ABSTRACT:

Background

Much controversy surrounds the association of traditional cardiovascular disease risk factors with venous thromboembolism (VTE).

Methods

We performed an individual level random-effect meta-analysis including 9 prospective studies with measured baseline cardiovascular disease risk factors and validated VTE events. Definitions were harmonized across studies. Traditional cardiovascular disease risk factors were modeled categorically and continuously using restricted cubic splines. Estimates were obtained for overall VTE, provoked VTE (ie, VTE occurring in the presence of 1 or more established VTE risk factors), and unprovoked VTE, pulmonary embolism, and deep-vein thrombosis.

Results

The studies included 244 865 participants with 4910 VTE events occurring duri

SUBMITTER: Mahmoodi BK 

PROVIDER: S-EPMC5201424 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature