MicroRNAs Modulate Pathogenesis Resulting from Chlamydial Infection in Mice.

ABSTRACT: Not all women infected with chlamydiae develop upper genital tract disease, but the reason(s) for this remains undefined. Host genetics and hormonal changes associated with the menstrual cycle are possible explanations for variable infection outcomes. It is also possible that disease severity depends on the virulence of the chlamydial inoculum. It is likely that the inoculum contains multiple genetic variants, differing in virulence. If the virulent variants dominate, then the individual is more likely to develop severe disease. Based on our previous studies, we hypothesized that the relative degree of virulence of a chlamydial population dictates the microRNA (miRNA) expression profile of the host, which, in turn, through regulation of the host inflammatory response, determines disease se

SUBMITTER: Yeruva L 

PROVIDER: S-EPMC5203655 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature