Listeria monocytogenes-Induced Cell Death Inhibits the Generation of Cell-Mediated Immunity.

ABSTRACT: The influence of cell death on adaptive immunity has been studied for decades. Despite these efforts, the intricacies of how various cell death pathways shape immune responses in the context of infection remain unclear, particularly with regard to more recently discovered pathways such as pyroptosis. The emergence of Listeria monocytogenes as a promising immunotherapeutic platform demands a thorough understanding of how cell death induced in the context of infection influences the generation of CD8+ T-cell-mediated immune responses. To begin to address this question, we designed strains of L. monocytogenes that robustly activate necrosis, apoptosis, or pyroptosis. We hypothesized that proinflammatory cell death such as necrosis would be proimmunogenic while apoptosis would be detrimental,

SUBMITTER: Theisen E 

PROVIDER: S-EPMC5203660 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature