Identification of Susceptible Loci and Enriched Pathways for Bipolar II Disorder Using Genome-Wide Association Studies.

ABSTRACT:

Background

This study aimed to identify susceptible loci and enriched pathways for bipolar disorder subtype II.

Methods

We conducted a genome-wide association scan in discovery samples with 189 bipolar disorder subtype II patients and 1773 controls, and replication samples with 283 bipolar disorder subtype II patients and 500 controls in a Taiwanese Han population using Affymetrix Axiom Genome-Wide CHB1 Array. We performed single-marker and gene-based association analyses, as well as calculated polygeneic risk scores for bipolar disorder subtype II. Pathway enrichment analyses were employed to reveal significant biological pathways.

Results

Seven markers were found to be associated with bipolar disorder subtype II in meta-analysis combining both discovery and replicat

SUBMITTER: Kao CF 

PROVIDER: S-EPMC5203756 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature