Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome.

ABSTRACT:

Background

The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system, we hypothesized that complement dysregulation is also important in infection-induced HUS.

Methods

Serological profiles (C3, FH, FI, AP activity, C3d, C3bBbP, C3b/c, TCC, αFH) and genetic profiles (CFH, CFI, CD46, CFB, C3) of the alternative complement pathway were prospectively determined in the acute and convalescent phase of disease in children newly diagnosed with STEC-HUS or aHUS. Serological profiles were compared with those of 90 age-matched controls.

Results

Thirty-seven patients were studied (26 STEC-HUS, 11 aHUS

SUBMITTER: Westra D 

PROVIDER: S-EPMC5203860 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature