Impact of tamoxifen therapy on fertility in breast cancer survivors.

ABSTRACT:

Objective

To determine whether tamoxifen use is associated with decreased ovarian reserve and decreased likelihood of having a child after a breast cancer diagnosis, using data from the Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women Study.

Design

Population-based cohort study.

Setting

Not applicable.

Patient(s)

Three hundred ninety-seven female breast cancer survivors aged 22-45 years whose cancer was diagnosed between ages 20 and 35 years and who were at least 2 years after diagnosis; 108 survivors also participated in a clinic visit.

Intervention(s)

None.

Main outcome measure(s)

Time to first child after cancer diagnosis, clinical measures of ovarian reserve (antimüllerian hormone [AMH] and antral follicle

SUBMITTER: Shandley LM 

PROVIDER: S-EPMC5203952 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature