Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells.

ABSTRACT: Circadian clocks regulate much of behavior and physiology, but the mechanisms by which they do so remain poorly understood. While cyclic gene expression is thought to underlie metabolic rhythms, little is known about cycles in cellular physiology. We found that Drosophila insulin-producing cells (IPCs), which are located in the pars intercerebralis and lack an autonomous circadian clock, are functionally connected to the central circadian clock circuit via DN1 neurons. Insulin mediates circadian output by regulating the rhythmic expression of a metabolic gene (sxe2) in the fat body. Patch clamp electrophysiology reveals that IPCs display circadian clock-regulated daily rhythms in firing event frequency and bursting proportion under light:dark conditions. The activity of IPCs and the rhythm

SUBMITTER: Barber AF 

PROVIDER: S-EPMC5204352 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature