Impact of renal impairment on cardiovascular disease mortality after liver transplantation for nonalcoholic steatohepatitis cirrhosis.

ABSTRACT:

Background & aims

Non-alcoholic steatohepatitis (NASH) is an independent risk factor for cardiovascular disease (CVD) morbidity after liver transplantation, but its impact on CVD mortality is unknown. We sought to assess the impact of NASH on CVD mortality after liver transplantation and to predict which NASH recipients are at highest risk of a CVD-related death following a liver transplant.

Methods

Using the Organ Procurement and Transplantation Network database, we examined associations between NASH and post-liver transplant CVD mortality, defined as primary cause of death from thromboembolism, arrhythmia, heart failure, myocardial infarction or stroke. A physician panel reviewed cause of death.

Results

Of 48 360 liver transplants (2/2002-12/2011), 5057 (10.5%) were

SUBMITTER: VanWagner LB 

PROVIDER: S-EPMC5204362 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature