Modulation of VEGF receptor 2 signaling by protein phosphatases.

ABSTRACT: Phosphorylation of serines, threonines, and tyrosines is a central event in signal transduction cascades in eukaryotic cells. The phosphorylation state of any particular protein reflects a balance of activity between kinases and phosphatases. Kinase biology has been exhaustively studied and is reasonably well understood, however, much less is known about phosphatases. A large body of evidence now shows that protein phosphatases do not behave as indiscriminate signal terminators, but can function both as negative or positive regulators of specific signaling pathways. Genetic models have also shown that different protein phosphatases play precise biological roles in health and disease. Finally, genome sequencing has unveiled the existence of many protein phosphatases and associated regulator

SUBMITTER: Corti F 

PROVIDER: S-EPMC5205541 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature