Molecular signatures of proliferation and quiescence in hematopoietic stem cells.

ABSTRACT: Stem cells resident in adult tissues are principally quiescent, yet harbor enormous capacity for proliferation to achieve self renewal and to replenish their tissue constituents. Although a single hematopoietic stem cell (HSC) can generate sufficient primitive progeny to repopulate many recipients, little is known about the molecular mechanisms that maintain their potency or regulate their self renewal. Here we have examined the gene expression changes that occur over a time course when HSCs are induced to proliferate and return to quiescence in vivo. These data were compared to data representing differences between naturally proliferating fetal HSCs and their quiescent adult counterparts. Bioinformatic strategies were used to group time-ordered gene expression profiles generated from micr

SUBMITTER: Venezia TA 

PROVIDER: S-EPMC520599 | biostudies-literature | 2004 Oct

REPOSITORIES: biostudies-literature